Reduction of cephamycin concentrations at the infection site in mice with experimental peritoneal infection caused by cephalosporinase-producing bacteria.
نویسندگان
چکیده
In an experimental model of peritoneal infection by cephalosporinase- (Ia and Ic) producing bacteria in mice, the reduction of cefoxitin, cefmetazole, and cefazolin concentrations in peritoneal fluid was observed in the mice infected with the Ia enzyme producer, whereas cefbuperazone concentrations were not reduced.
منابع مشابه
P-146: Toxoplasmosis: Experimental Vaginal Infection in NMRI Mice and Effect on Uterin,Placenta and Fetus Tissues
Background: Toxoplasma gondii is an important zoonotic pathogen. Vertical transmission of the parasite occurs when females were infected primarily during gestation. This parasite transmitted to the fetus through the placenta and may cause miscarriage, permanent neurological damage, premature birth and visual impairment. Materials and Methods: Two 6-8-week NMRI females mice were crossed with one...
متن کاملOptimization condition in labeling of Ofloxacin with 99mTc and its biological evaluation in Staphylococcus aureus and Escherichia coli for infection imaging
Introduction: The use of radiopharmaceuticals is a powerful tool in the management of patients with infectious or inflammatory diseases in nuclear medicine. In this study ofloxacin as a second-generation fluoroquinolone is used to design a desired infection imaging agent after labeling with 99mTc via direct labeling. Methods: Ofloxacin was radiolabeled with 99mTc using di...
متن کاملThe effect of ZnO nanoparticles on bacterial load of experimental infectious wounds contaminated with Staphylococcus aureus in mice
Objective (s): Bacterial infection is an important cause of delayed wound healing. Staphylococcus aureus (S. aureus) is the main agent causing these infections. Zinc Oxide (ZnO) nanoparticles have antibacterial activity and also accelerate the wound healing process. The aim of the present study is to evaluate the effect of ZnO nanoparticles on bacterial load reduction of the wound infection. M...
متن کاملFrequency of ESBL in Surgical Site Infection at a Tertiary Care Hospital
Background: Infection caused by ESBL in the surgical site infection is very alarming. Objective: The purpose of the present study was to see the status of ESBL bacteria isolated from surgical site infection with their antimicrobial sensitivity pattern. Methodology: This cross sectional study was conducted in the Department of Microbiology at Dhaka Medical College, Dhaka from January, 2005 to De...
متن کاملThe antibacterial activity of ticarcillin/clavulanic acid (BRL28500) against ticarcillin-resistant bacteria.
The efficacy of BRL28500, a formulation of ticarcillin (TIPC, 15 parts) and clavulanic acid (CVA, 1 part), against TIPC-resistant strains of Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae was studied both in vitro and in vivo. The MICs of BRL28500 against these beta-lactamase producing strains were lower than those of TIPC or CVA alone against such strains. When BRL28500 was ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 29 2 شماره
صفحات -
تاریخ انتشار 1986